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CHARLES DYSON, M.D.

Arch Ophthal. 1949;42(4):416-421.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IONTOPHORESIS of therapeutic agents capable of ionization has been shown to give high intraocular concentrations of these substances. Since the epithelium of the excised cornea not only is virtually impermeable to electrolytes¹ but also possesses a high degree of electrical resistance,² the undamaged cornea would seem to be unsuited to the iontophoretic transfer of ions.

The appearance of a transient epithelial haze after the use of iontophoresis has been noted by several investigators.³ This is usually reported as clearing within a few hours, but in 1 case a 4 mm. nebula persisted three weeks after treatment.^3a These observations considered with the finding that damage to the corneal epithelium increases its permeability to penicillin⁴ lead one to suspect that the reported efficacy of iontophoresis may be due to epithelial injury. Von Sallmann clearly demonstrated by in vivo experiments that the iontophoretic transfer of penicillin into and . . . [Full Text PDF of this Article]

Author Affiliations
LONDON, ONTARIO, CANADA

From the Howe Laboratory of Ophthalmology, Harvard Medical School.

Footnotes
Medical Research Fellow, National Research Council of Canada.

This paper has been accepted in completion of requirements for the Diploma in Ophthalmology of McGill University, Montreal, Canada

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