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O. GARTH FITZHUGH, Ph.D.; WILHELM H. BUSCHKE, M.D.

Arch Ophthal. 1949;41(5):572-582.

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SINCE Bouchard's¹ discovery in 1886 that naphthalene produced cataract in rabbits, a large number of experimental papers have been published on the subject. Relatively few authors, however, have attempted to approach the mechanism of this production of cataract by studying the cataractogenic properties of chemically related substances. Kolinski² failed to produce cataract with nitronaphthalene, β-naphthol and anthracene. Salffner³ had negative results with 1,5-dioxynaphthalene, 2,3-dioxynaphthalene and 2,7-dioxynaphthalene. He found the cataractogenic properties of naphthalene greatly enhanced by phthalic acid; however, control experiments with other agents which likewise produced renal damage led him to conclude that the effect was a result of damage to the kidney, producing a delayed excretion of naphthalene or a toxic derivative. Igersheimer and Ruben⁴ reported negative results with both a- and β-naphthol, while van der Hoeve⁵ produced cataracts in rabbits with β-naphthol. Jess⁶ observed occasional fine reversible clefts and opacities in . . . [Full Text PDF of this Article]

Author Affiliations
WASHINGTON, D. C.; BALTIMORE

From the Division of Pharmacology, Food and Drug Administration, Federal Security Agency, Washington, D. C., and the Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine.

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