This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Citing articles on Web of Science (25)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

PARKER HEATH, M.D.; C. W. GEITER, M.D.

Arch Ophthal. 1949;41(2):172-177.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE FIRST studies on the ocular use of phenylephrine hydrochloride (neo-synephrine hydrochloride®) were begun in 1933 and reported in 1936.¹ Since then, extensive clinical experiences with this drug have accumulated with additional observations. The object of this article is to review these data, bringing them up to date.

Phenylephrine hydrochloride (laevo--hydroxy-β-methylamino-3-hydroxyethylbenzene hydrochloride) is the salt of the laevo isomer of a synthetically prepared derivative of phenylethylamine. It is a white, crystalline, nonhygroscopic compound, readily soluble in water and alcohol. It is relatively stable. The melting point ranges from 138 to 142 C.

Pharmacologically, phenylephrine belongs to the group of compounds possessing sympathomimetic activity. It is an active vasopressor agent when given either orally or parenterally. As a vasoconstrictor, it has the desirable quality of rarely causing any compensatory dilatation. Phenylephrine relaxes the sphincter muscle of the iris and strongly contracts the radial fibers. This characteristic, together with its pronounced . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON; NORTH KANSAS CITY, MO.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?