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IRVING H. LEOPOLD, M.D., D.Sc.

Arch Ophthal. 1945;34(2):99-102.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In recent years attention has been directed to the value of detergents in ophthalmology. Although they are being used as germicides and cleansing agents,¹ most of the ophthalmologic consideration has been devoted to their penetrant action, i. e., to their ability to aid in increasing the penetration of therapeutically active substances through the cornea. O'Brien and Swan² demonstrated that the intraocular penetration of carbaminoylcholine chloride could be enhanced by the use of 0.1 per cent zephiran chloride, 1 per cent saponin, 0.1 per cent Duponol PC or 0.1 per cent Aerosol OT. Other investigators followed this lead and showed that the intraocular penetration of other locally applied drugs could be increased by the use of detergents. Bellows and Gutmann³ demonstrated the increased penetration of sulfonamide compounds when such detergents as Aerosol OS, Aerosol OT, Tergitols 4, 7 and 08, Ocenol KD (oleyl alcohol), sodium lauryl sulfate and . . . [Full Text PDF of this Article]

Author Affiliations
PHILADELPHIA

From the Department of Ophthalmology, the School of Medicine of the University of Pennsylvania.

Footnotes
The work described in this paper was done under a contract, recommended by the Committee on Medical Research, between the Office of Scientific Research and and Development and the University of Pennsylvania.

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