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IRVING H. LEOPOLD, M.D., D.Sc.; WILLARD H. STEELE, M.D.

Arch Ophthal. 1945;33(6):463-467.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

There have appeared excellent reviews by Bellows,¹ Alvaro,² Thygeson³ and Wagener⁴ concerning the toxic properties of the sulfonamide compounds on ocular structures. Although much has been written about the toxic influence of these compounds on wound healing elsewhere in the body, only recently has consideration been given to their influence on healing of ocular wounds. Bellows considered this property in his review in June 1943. The data for these conclusions were based on the experimental work of Bellows and Gluckman.⁵ These authors concluded that locally applied sulfonamide compounds greatly deter regeneration of corneal epithelium. Berens, De Gara and Loutfallah⁶ demonstrated in 1943 that the average healing time of the wounds of the cornea treated with sulfonamide ointment or with the ointment base alone was usually greater than the average healing time of the untreated eyes. They suggested that the local use of the sulfonamide . . . [Full Text PDF of this Article]

Author Affiliations
PHILADELPHIA

From the Department of Ophthalmology of the University of Pennsylvania.

Footnotes
The work described in this paper was done under a contract, recommended by the Committee on Medical Research, between the Office of Scientific Research and Development and the University of Pennsylvania.

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