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IRVING H. LEOPOLD, M.D., D.Sc.; WILLIAM O. LaMOTTE, Jr., M.D.

Arch Ophthal. 1945;33(1):43-46.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

PENETRABILITY OF PENICILLIN

Struble and Bellows¹ pointed out that in the evaluation of any chemotherapeutic agent the efficiency of the agent depends not only on its antibacterial potency but on its diffusibility and its concentration in the infected part. Von Sallmann and Meyer² and Struble and Bellows¹ studied the penetration of penicillin in the normal eyes of rabbits and dogs.

Von Sallmann and Meyer² were unable to demonstrate any antibacterial activity of penicillin in the aqueous humor after repeated applications of solutions and ointments containing penicillin to the normal rabbit eye, but obtained high levels of penicillin in the aqueous with the corneal bath and iontophoretic technics. Struble and Bellows¹ also demonstrated high concentrations of penicillin in the aqueous humor after corneal baths of penicillin and showed that the level in the cornea exceeded the level in the aqueous when the corneal bath technic was . . . [Full Text PDF of this Article]

Author Affiliations
PHILADELPHIA

From the Department of Ophthalmology, University of Pennsylvania School of Medicine.

Footnotes
Read at a meeting of the College of Physicians of Philadelphia, Dec. 21, 1944.

The work described in this paper was done under a contract recommended by the Committee on Medical Research, between the Office of Scientific Research and Development and the University of Pennsylvania.

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