To the Editor :
—Luis Castellanos A., of Chihuahua, Mexico, published a fascinating article entitled "Ariboflavinosis as a Probable Cause of Vernal Conjunctivitis" in the March issue (ARCH. OPHTH.31: 214, 1944). I disagree with the author's theory, which lacks scientific confirmation.
I am amazed that Dr. Castellanos has made no mention of vernal conjunctivitis as an ocular manifestation of an allergic state. The literature is replete with experimental evidence of its allergic origin. The clinical symptoms of the disease have been produced out of season by inserting in the conjunctival cul-de-sac pollens to which the patient was shown to be sensitive by intradermal tests during seasonal attacks.
The periodicity of vernal conjunctivitis in correspondence with the pollenation of the trees, grasses and weeds is no more coincidental than the onset of autumnal hay fever, which begins on or about August 15. The approach of warm weather in April coincides with
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