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ROBERT R. CHACE, M.D.

Arch Ophthal. 1943;30(1):75-86.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

For many years research has been carried out on the problem of the cellular response in the developing nervous system to the presence or absence of peripheral stimuli. Detwiler,¹ working with amphibian larvae, demonstrated the hyperplasia of sensory ganglions when they were connected with a transplanted limb. That the central nervous system responds to increased peripheral stimuli by an excessive proliferation of cellular elements has been demonstrated clearly by Burr,² who showed that there is a definite hyperplasia in the pars dorsalis thalami and in the cerebral hemisphere when an additional nasal placode is grafted adjacent to the normal one in Amblystoma. Further, Hamburger³ showed that the motor horn areas of the cord underwent a hyperplasia when limb primordia were grafted in chick embryos. The opposite procedure, removal of an end organ, has been shown to bring about a hypoplasia in the central nervous system, in the . . . [Full Text PDF of this Article]

Author Affiliations
PROVIDENCE, R. I.

From the Department of Anatomy, Columbia University College of Physicians and Surgeons, and the Institute of Ophthalmology, Presbyterian Hospital.

Footnotes
Prof. Samuel R. Detwiler, Department of Anatomy, gave helpful suggestions and guidance in the carrying out of this study.

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