This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

JOHN G. BELLOWS, Ph.D., M.D.

Arch Ophthal. 1943;29(6):888-903.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In the last few years new chemotherapeutic agents have made their appearance. These consist of the well known sulfonamide compounds, already proved valuable clinically, and lesser known substances derived from molds, fungi and bacilli, e. g. penicillin from penicillium, tyrothricin from soil bacteria and actinomycosin from actinomyces. The ophthalmologic literature contains practically no reference to the latter substances. Fleming¹ stated that penicillin is approximately four times as potent as sulfathiazole (2-[paraaminobenzenesulfonamido]-thiazole), twenty times as potent as sulfapyridine (2-[paraaminobenzenesulfonamido]-pyridine) and one hundred times as potent as sulfanilamide. Penicillin has an important advantage over sulfanilamide in that it is far less toxic and is not inhibited by secretions, pus and large numbers of organisms. Tyrothricin consists of 15 per cent gramicidin and 85 per cent tyrocidin, both of which show marked bactericidal powers for gram-positive organisms. Gramicidin, about twenty-five to fifty times more potent than tyrocidin, is effective in amounts as . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

From the Department of Ophthalmology, Northwestern University Medical School.

Footnotes
Read before the American Academy of Ophthalmology and Otolaryngology, Chicago, Oct. 11, 1942.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?