This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

IRVING H. LEOPOLD, M.D.; HAROLD G. SCHEIE, M.D., D.Sc.

Arch Ophthal. 1943;29(5):811-817.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Recently a new form of the sulfonamide compounds was developed. This is the microcrystalline form produced by either sonic vibration or use of some rapid mixing device.¹ The chief difference from the ordinary sulfonamide compounds is the smaller size of the crystals, which renders more surface available and also permits passage through a 26 gage needle of concentrations as high as 20 per cent.

Studies were undertaken in an attempt to evaluate this new physical property in ophthalmology. In a recent article² we showed that the ratio between the concentrations of sulfathiazole (2-[paraaminobenzenesulfonamido]-thiazole) in the aqueous and in the blood of cats with approximately the same with intraperitoneal injection of microcrystalline and oral administration of macrocrystalline sulfathiazole.

Both Guyton³ and Chinn and Bellows⁴ have demonstrated the relatively greater penetration of sulfanilamide than of its derivatives when applied locally. They showed that sulfathiazole penetrated into the aqueous . . . [Full Text PDF of this Article]

Author Affiliations
PHILADELPHIA

From the Department of Ophthalmology, University of Pennsylvania School of Medicine.

Footnotes
The microcrystalline preparations used in this study were supplied by and the work aided by a grant from the Smith, Kline & French Laboratories.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?