
ROLE OF ASCORBIC ACID (VITAMIN C) IN SECRETION OF INTRAOCULAR FLUID
JONAS S. FRIEDENWALD, M.D.;
WILHELM BUSCHKE, M.D.;
HARRY O. MICHEL, Ph.D.
Arch Ophthal. 1943;29(4):535-574.
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OUTLINE
- Introduction
- Redox substances in the ciliary body
- Titration and identification
- Technic
- Results
- Summary
- Location of redox substances in the tissues
- Ascorbic acid
- Glutathione
- Summary
- Ascorbic acid in the mechanism of secretion of intraocular fluid
- Redox substances in the ocular tissues of guinea pigs
- Oxidation-reduction potential
- Irreciprocal permeability to dyes
- Transfer of water
- Mechanism of storage of ascorbic acid
- Intraocular secretion of ascorbic acid
- Intraocular secretory systems without ascorbic acid
- Comment
- Summary
INTRODUCTION
In a previous paper1 certain components of the secretory mechanism in the ciliary body were described and a theory was formulated to explain their interaction. The present study is a continuation of the same investigation. Ascorbic acid (vitamin C) is a substance derived from the blood but present in the intraocular fluid in a concentration appreciably higher than in the blood.2 Energy must be expended by the tissues to maintain the difference in concentration. The
. . . [Full Text PDF of this Article]
Author Affiliations
BALTIMORE
From the Wilmer Ophthalmological Institute of the Johns Hopkins University and Hospital.
Footnotes
This investigation was supported in part by a grant from the John and Mary R. Markle Foundation. The work was presented in part before the American Ophthalmological Society June 7, 1939.
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