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C. S. O'BRIEN, M.D.; K. C. SWAN, M.D.

Arch Ophthal. 1942;27(2):253-263.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Carbaminoylcholine is one of a group of synthetic choline derivatives which act principally by parasympathetic stimulation. In chemical structure (chart 1) it is similar to acetylcholine, but its action is more prolonged, since it is stable in the tissues and hydrolysis is slow.

The initial experiments on the ocular effects of carbaminoylcholine chloride were made on isolated iris sphincter and indicated that this drug may be the most powerful of all known miotics.¹ However, clinical reports have been conflicting. Guyton² in a recent review of the líterature found no unanimity of opinion regarding the degree and the duration of miosis but concluded that the miosis is probably greater but less prolonged than that produced by similar concentrations of pilocarpine. Velhagen³ found the effect of a 0.75 per cent concentration of carbaminoylcholine chloride on the accommodation of the normal human eye to be less than that of a . . . [Full Text PDF of this Article]

Author Affiliations
IOWA CITY

From the Department of Ophthalmology, State University of Iowa College of Medicine.

Footnotes
Read at the Seventy-Seventh Annual Meeting of the American Ophthalmological Society, Hot Springs, Va., May 30, 1941.

The carbaminoylcholine chloride (doryl) for this study was supplied by Merck & Co., Inc. Zephiran was supplied by the Alba Pharmaceutical Co.