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BUFFERED, ISOTONIC AND PRESERVED

LOUIS ARRIGONI, M.S.; LOUIS FISCHER, Ph.D.; G. A. TOZER, B.S.

Arch Ophthal. 1941;26(5):852-858.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Zinc sulfate solutions in varying concentrations have been used in the practice of ophthalmology for many years. However, in spite of their long popularity as ophthalmic medicaments, almost all such solutions as ordinarily dispensed have two disadvantages. First, they are irritating to the delicate corneal tissues and, as a result, produce excessive lacrimation. This condition causes the active ingredients to be washed from the eye, thus greatly decreasing the therapeutic effectiveness of the zinc sulfate. Secondly, most of the preparations are dispensed unpreserved and contain zinc sulfate in combination with boric acid—a mixture which constitutes an admirable medium for the growth of microorganisms such as yeasts and molds.¹

We have undertaken the present study in an effort to produce non-irritating and preserved zinc sulfate solutions which will lend themselves to more effective medication of the eyes than most such solutions now in common use. The adjustments made on ordinary . . . [Full Text PDF of this Article]

Author Affiliations
Assistant State Chemist, College of Pharmacy, University of Washington; Associate Professor of Pharmaceutical Chemistry, College of Pharmacy, University of Washington SEATTLE; EVERETT, WASH.

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