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John G. Bellows, M.D., Ph.D.; Herman Chinn, Ph.D.

Arch Ophthal. 1941;25(2):333-334.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In response to some inquiries received by this department concerning the use of homatropine and paredrine (4-hydroxy--phenyl-β-aminopropine; β-4-hydroxylphenylisopropylamine) at various p_h levels, we investigated their solubility and reaction in buffer solutions. Homatropine hydrobromide and paredrine hydrobromide¹ were employed in concentrations of 5 per cent and 2 per cent respectively. The buffer solutions were prepared according to Gifford.² All p_h determinations were made by means of a glass electrode.

In the p_h range investigated (4.20 to 8.75) the solutions remained perfectly clear after addition of the drugs. A slight alteration in the reaction of the buffer, varying from 0.05 to 0.35 p_h unit, was noted. The

greatest changes occurred in the more alkaline solutions. At p_h levels above 6.15 the shift was to the acid side, whereas at p_h 4.6 the solution became slightly more alkaline.

Buffer solution no. 1,² used as . . . [Full Text PDF of this Article]

Author Affiliations
Chicago

From the Department of Ophthalmology and Chemistry, Northwestern University Medical School.

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