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WITH SPECIAL REFERENCE TO INTRAOCULAR TENSION

ABRAHAM MYERSON, M.D.; WILLIAM THAU, M.D.

Arch Ophthal. 1940;24(4):758-760.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Furfuryl trimethyl ammonium iodide is a new parasympathetic drug, having the following structural formula :

The animal pharmacology was developed by Fellows and Livingston,¹ who introduced the drug. They found that the drug is very stable in blood and produces a marked fall in blood pressure, cardiac inhibition and depression, an increased flow of saliva and an increased tone of intestine and bladder. These effects were overcome by atropine.

Myerson, Rinkel, Loman and Dameshek² have contributed the first paper on its pharmacology in man. The drug is effective by mouth in doses of from 5 to 20 mg. By intramuscular injection, 1 to 5 mg. will produce the full physiologic effects. These are, in general, similar to those produced by acetylbetamethylcholine (mecholyl chloride; mecholyl bromide), although differing in certain important respects. There are marked flushing, sweating and a drop in temperature which is probably the result of the sweating; . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON

From the Division of Psychiatric Research, Boston State Hospital.

Footnotes
Aided by grants from the Commonwealth of Massachusetts, the Rockefeller Foundation and the Works Progress Administration Project No. 18088.

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