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LORAND V. JOHNSON, M.D.; ROBERT E. ECKARDT, M.S.

Arch Ophthal. 1940;23(5):899-907.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In a previous communication observations on the corneas of rats whose diet was deficient in riboflavin (vitamin B₂) were recorded. At that time we said : "From our experience with the diet deficient in riboflavin, the most consistent ocular change was the appearance of corneal vascularization. . . . After riboflavin was added, the most uniform effect was remission of vascularization."¹ While the article was in press, a similar opinion was expressed by Bessey and Wolbach :² "Vascularization of the cornea is an early and constant phenomenon in albino rats in riboflavin deficiency. It precedes all other demonstrable lesions of the deficiency." Conspicuous cutaneous features are intense flushing of the skin and alopecia.

A chemical and pharmacologic description of riboflavin follows:

Riboflavin is the name which was proposed by the Council on Pharmacy and Chemistry of the American Medical Association³ for the compound 6,7-dimethyl-9(d,1'-ribityl)-isoalloxazin, which has the structure shown in figure . . . [Full Text PDF of this Article]

Author Affiliations
CLEVELAND

From the Western Reserve University School of Medicine and the University Hospitals of Cleveland, Department of Surgery, Ophthalmologic Service.

Footnotes
Fellow in biochemistry, recipient of the George Angell and the General Biochemicals, Inc., stipends for research in ophthalmology.

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