This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

R. TOWNLEY PATON, M.D.

Arch Ophthal. 1939;22(3):377-384.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Neoprontosil, formerly called prontosil soluble or prontosil, is disodium sulfamidophenyl-2'-azo-7'-acetylamino-1'-hydroxynaphthalene-3',6'-disulfonate. It is employed in a 2.5 or 5 per cent aqueous solution or in tablets. Its action on the various infective organisms in the body is similar to that of sulfanilamide (paraaminobenzenesulfonamide) but not identical. Long, Bliss and Feinstone¹ assumed from results of experiments on animals that its action depends on the chemical reduction in the body. There is a relatively small amount of sulfanilamide present in the solution; on analysis neoprontosil yields only 11 grains, or 0.7 Gm., of sulfanilamide per hundred cubic centimeters of the 2.5 per cent solution.

Much has already been written on the use of sulfanilamide in the treatment of trachoma and gonococcic infections of the eye. The names of Loe,² Rychener,³ Lian,⁴ Kirk, McKelvie and Hussein⁵ and Thygeson⁶ should be mentioned for the favorable results obtained in the . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the clinic of the Manhattan Eye, Ear and Throat Hospital.

Footnotes
Read before the New York Academy of Medicine, Section of Ophthalmology, Feb. 20, 1939.

This work was aided by the generosity of the Medical Department of the Winthrop Chemical Co., Inc.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?