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VIII. VASCULAR CHANGES IN THE EYES

JOHN E. L. KEYES, M.D.; HARRY GOLDBLATT, M.D., C.M.

Arch Ophthal. 1938;20(5):812-828.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In healthy dogs and monkeys (macaques) persistent elevation of the systolic and the diastolic pressure, with or without a decrease of renal excretory function, followed permanent partial constriction of the main renal arteries.¹

The eyes of these hypertensive animals have been studied during a period of more than five years. A preliminary report² and an interim report³ have been made.

These dogs exhibited two definite types of hypertension: a benign phase, without a decrease of renal excretory function, and an acute malignant phase, with very high blood pressure and severe damage of the renal excretory function. These two phases correspond to the benign and malignant phases of essential hypertension in man. The acute malignant phase of hypertension occurred, or was produced, in dogs already hypertensive, owing to constriction of the main renal arteries when the arteries were reconstricted to a great degree, or in healthy dogs in . . . [Full Text PDF of this Article]

Author Affiliations
CLEVELAND

From the Institute of Pathology and the Department of Ophthalmology, Western Reserve University.

Footnotes
Read before the Section on Ophthalmology at the Eighty-Ninth Annual Session of the American Medical Association, San Francisco, June 16, 1938.

This study was supported by the Beaumont-Richman-Kohn Fund, and by special grants-in-aid from the Josiah Macy Jr. Foundation and Mr. N. L. Dauby, Mr. Alex S. Winter and associates, Cleveland.