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FACTORS INFLUENCING PROGRESSIVE AND REGRESSIVE CHANGES

HELEN S. MITCHELL, Ph.D.; GLADYS M. COOK, M.S.

Arch Ophthal. 1938;19(1):22-33.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The observation that galactose is unique as an etiologic factor in the production of experimental cataract in rats was first reported by Mitchell¹ and later confirmed by Yudkin² and Day.³ The earlier work with lactose and other sugars⁴ led to the realization that it was probably the galactose fraction of the lactose molecule which caused the injury. Galactose has supplanted lactose for the production of most of the experimental cataracts in the laboratory of the Massachusetts Agricultural Experiment Station because of the more rapid and consistent results obtained. Whichever sugar is used, however, it is logical to speak of galactose cataract in contrast to the vitamin G deficiency cataract. Both may well be designated as nutritional cataracts.

The fact that the rat is susceptible to lenticular changes as a result of vitamin G deficiency or of intolerance for galactose makes it a valuable experimental animal . . . [Full Text PDF of this Article]

Author Affiliations
AMHERST, MASS.

Footnotes
This paper is Contribution No. 281 of the Massachusetts Agricultural Experiment Station.

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