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Paul L. Kaufman, MD

Arch Ophthalmol. 1997;115(7):911-913.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

PROSTAGLANDIN F₂ and its analogues are the most potent and efficacious topical ocular hypotensive agents currently known.^1-7 Their hypotensive action results primarily, if not exclusively, from enhancement of uveoscleral drainage of aqueous humor,^8,9 in turn consequent to relaxation of the ciliary muscle^10-12 and remodeling of the connective tissue between the outer longitudinal muscle bundles.^13-15 The latter probably results from prostaglandin-stimulated induction of matrix metalloproteinase enzymes.¹⁶

See also page 857

Prostaglandins are autacoids, ie, hormones that are synthesized and released, act locally,¹⁷ and probably play a role in the normal endogenous regulation of aqueous outflow. They are produced by human trabecular endothelial¹⁸ and ciliary muscle cells¹⁹ in culture and are released by various ocular tissues during many types of ocular inflammation.¹⁷ During such inflammatory episodes, the trabecular meshwork could be impaired directly by the inflammatory process or obstructed by cellular debris . . . [Full Text PDF of this Article]

Author Affiliations
Madison, Wis

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