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Gesa A. Stroman, MD; William C. Stewart, MD; Karl C. Golnik, MD
Charleston, SC

Arch Ophthalmol. 1996;114(1):105.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In reply

We appreciate Dr Wilson's interest in our article, and we wish to comment on the issues he raised. Since a pathophysiologic correlation of confluent deep white matter lesions with small-vessel ischemia or arteriolosclerosis exists,^1,2 this implies that evidence of ischemic injury may be drawn from MRI. We did not base our diagnosis of ischemia on cognitive defects but merely stated that a clinical correlation has been made to the presence of confluent deep white matter lesions. Although a total cross-sectional area would be an interesting way to measure the defects, this does not have to be performed to make the diagnosis or a statistical analysis.^1,2

With regard to age, as stated in the paper, we evaluated if our confluent deep white matter lesions were a function only of age. We found that the average age of people with multiple isolated (clinically unimportant) lesions was similar to . . . [Full Text PDF of this Article]

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