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A Valid Model for Both Early and Late Stages of Diabetic Retinopathy

Robert N. Frank, MD

Arch Ophthalmol. 1995;113(3):275-276.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

AN ACCURATE animal model of a human disease can help us to understand the pathogenesis of the disease, to study its cellular and molecular mechanisms of progression, and to test new therapeutic approaches before they are ready for evaluation in human subjects. The model of diabetic retinopathy in the long-term galactosemic dog, introduced by Engerman and Kern¹ in 1984, is one of the best animal models now available in ophthalmic research. After 3 to 5 years on a diet containing 30% galactose, these animals accurately reproduce the lesions of early diabetic retinopathy in humans, and they do so following chronic elevation of an aldohexose that is structurally similar to glucose but does not enter into many of the biochemical pathways by which glucose is metabolized. In this issue of the ARCHIVES, Engerman and Kern² and Kador et al³ report important new findings using this model that appear . . . [Full Text PDF of this Article]

Author Affiliations
Detroit, Mich

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