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Edward W. D. Norton, MD
Miami, Fla

Arch Ophthalmol. 1993;111(11):1460.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

As a member of the Data Safety and Monitoring Committee for the recent study by Berson et al,¹ I have difficulty accepting the conclusions that "These results support a beneficial effect of 15 000 IU/d of vitamin A..." for several reasons.

First, in the study design, patients were assigned to one of four treatment groups as follows: 15 000 IU/d of vitamin A, plus 3 IU/d of vitamin E (group A); 75 IU/d of vitamin A, plus 3 IU/d of vitamin E (trace group); 15 000 IU/d of vitamin A, plus 400 IU/d of vitamin E (group A+E); and 75 IU/d of vitamin A, plus 400 IU/d of vitamin E (group E).

The data through years 4 and 5 show no significant difference between group A and the trace group (Table and Figure). The authors fail to address these data. Instead, the analysis combines group A and group A+E . . . [Full Text PDF of this Article]

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