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Albert Alm, MD
Uppsala, Sweden

Jörgen Villumsen, MD
Ume, Sweden

Arch Ophthalmol. 1992;110(8):1042.

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In Reply.

—We appreciate Dr Kaufman's comment on our recent article¹ on the effect of the prostaglandin analogue PhXA34 on aqueous humor dynamics. From that study, as well as previous studies on prostaglandin F₂-isopropylester, we can conclude that neither prostaglandin F₂ nor its analogue, PhXA34, reduce pressure in the human eye by reducing aqueous flow. In primates, there is ample evidence that increased uveoscleral outflow explains most, if not all, of the reduction in eye pressure.^2-3 No clinical technique is available to determine uveoscleral flow, and estimates of changes in uveoscleral flow must be based on indirect evidence. The fact that the change in total outflow facility that we found was too small to explain the observed pressurelowering effect substantiates the assumption that increased uveoscleral outflow is also involved in humans. That was, to us, the most important conclusion that can be drawn from our . . . [Full Text PDF of this Article]

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