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Facilitating Aqueous Outflow by Assaulting the Meshwork Cytoskeleton, Junctional Complexes, and Extracellular Matrix

Paul L. Kaufman, MD

Arch Ophthalmol. 1992;110(1):34-36.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The report by Liang et al¹ in this issue is significant for two reasons. It illustrates the power of the isolated preparation of organ-cultured human anterior ocular segment in identifying and studying the mechanism of action of potential new antiglaucoma pharmacologic agents. Such studies are usually performed initially in subprimate mammals, then in subhuman primates, and finally in the living human eye. While animal studies are useful, the physiologic and anatomic characteristics of subprimate mammals are often sufficiently different from those of humans to make extrapolation difficult. Primate studies are more relevant, but far more costly and difficult. With increasing concern over the use of animals, especially primates, in biomedical research, these studies have become even more difficult and expensive, threatening the efficient and costeffective development of new antiglaucoma medications. The advent of cell culture technology has brought some relief by allowing study of the effects of pharmacologic agents . . . [Full Text PDF of this Article]

Author Affiliations
Madison, Wis

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