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Theo L. van der Schaft, MD; Wim C. de Bruijn, PhD; Cornelia M. Mooy, MD; Diane A. M. Ketelaars, BSc; Paul T. V. M. de Jong, MD, PhD
Rotterdam, the Netherlands

Arch Ophthalmol. 1992;110(1):16.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In Reply.

—We appreciate the interest of Drs Loeffler and Lee in our study of the ultrastructural nature and distribution of BLD. We would like to clarify the issues mentioned in their letter.

To study this aging change, we selected 42 postmortem normal human eye bank eyes without any known macroscopic or microscopic pathologic conditions, in contrast to Loeffler and Lee,¹ who studied nine eyes of which seven eyes were surgically enucleated for pathologic changes other than agerelated macular degeneration.

Before comparing the ultrastructure of the maculae with and without BLD, we first examined 7-µm Mallory-stained sections of one half of the macula with light microscopy. Even small deposits of BLD under a single retinal pigment epithelial cell are clearly visible without using oil immersion due to the excellent color contrast between BLD and the retinal pigment epithelium as described by Sarks.² To minimize the chance of overlooking . . . [Full Text PDF of this Article]

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