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Susan G. Elner, MD; Victor M. Elner, MD, PhD
Ann Arbor, Mich

Daniel M. Albert, MD
Boston, Mass

Michael Arnall, MD
Fort Myers, Fla

Arch Ophthalmol. 1991;109(3):322.

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In Reply.

—We appreciate the comments by Massicotte et al. As with every other clinical or laboratory test, the finding of hemosiderin in tissue must be interpreted in the context of clinical history and pathologic findings. When so used, we believe that iron stains for hemosiderin may be helpful in dating hemorrhages. Although Massicotte et al refer to general pathology texts in an incomplete discussion concerning the deposition of hemosiderin, the timing of iron deposition in traumatic brain lesions is well documented.^1-4 Hemosiderin first appears 3 days after injury, but does not become obvious on histochemical staining for 5 to 7 days after trauma.^1-4 In two of three cases in our report,⁵ the children died within 3 days of hospital admission. In the third case, death occurred on the sixth day of hospitalization, but histologic evidence for hemorrhages of different ages was incontrovertible (see below). In all . . . [Full Text PDF of this Article]

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