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James R. Boynton, MD; S. Scott Searl, MD
Rochester, NY

Arch Ophthalmol. 1985;103(2):175-179.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.

—Drs Doxanas and Green¹ have written an informative, useful article on sebaceous gland carcinoma. However, one statement concerning treatment is open to question: "If the pagetoid involvement is quite diffuse, one may elect to excise the carcinoma using frozen-section control, and leave the conjunctiva and lid margins intact if the patient can be followed-up closely."

We do not believe there is any evidence to suggest that this is a safe form of treatment. On the contrary, every piece of evidence suggests the opposite. There is no question that sebaceous gland carcinoma is an aggressive, potentially lethal tumor. Knowingly leaving tumor cells in the eyelid must be viewed as dangerous. We do not know the biologic potential of these "pagetoid" or intraepithelial carcinoma cells. The authors pointed out that in some series, pagetoid involvement has been associated with increased mortality.² It appears that early diagnosis and . . . [Full Text PDF of this Article]

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