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Min Wang, MD; Donald C. Hood, PhD; Jung-Suk Cho; Quraish Ghadiali, BA; Gustavo V. De Moraes, MD; Xian Zhang, PhD; Robert Ritch, MD; Jeffrey M. Liebmann, MD

Arch Ophthalmol. 2009;127(7):875-881.

Objective  To explore the feasibility of obtaining a local measurement of the thickness of the retinal ganglion cell layer in patients with glaucoma using frequency-domain optical coherence tomography (fdOCT) and a computer-aided manual segmentation procedure.

Methods  The fdOCT scans were obtained from the horizontal midline for 1 eye of 26 patients with glaucoma and 20 control subjects. The thickness of various layers was measured with a manual segmentation procedure aided by a computer program. The patients were divided into low- and high-sensitivity groups based on their foveal sensitivity on standard automated perimetry.

Results  The RGC plus inner plexiform and the retinal nerve fiber layers of the low-sensitivity group were significantly thinner than those of the high-sensitivity group. While these layers were thinner in the patients than the controls, the thicknesses of inner nuclear layer and receptor layer were similar in all 3 groups. Further, the thinning of the retinal ganglion cell plus inner plexiform layer in 1 glaucoma-affected eye showed qualitative correspondence to the loss in 10-2 visual field sensitivity.

Conclusions  Local measures of RGC layer thickness can be obtained from fdOCT scans using a manual segmentation procedure, and these measures show qualitative agreement with visual field sensitivity.

Author Affiliations: Departments of Psychology (Drs Wang, Hood, and Zhang, Ms Cho, and Mr Ghadiali) and Ophthalmology (Dr Hood), Columbia University, New York, New York; Einhorn Clinical Research Center, New York Eye and Ear Infirmary (Drs De Moraes, Ritch, and Liebmann), New York, New York; and the Department of Ophthalmology and Visual Science, Shanghai Medical School, Eye, Ear, Nose, and Throat Hospital, Fudan University, Shanghai, China (Dr Wang).

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