This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (11)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Neurology  • Neuro-ophthalmology  • Corneal Disorders  • Glaucoma  • Ophthalmological Disorders, Other  • Articles for Residents  • Hypertension  • Alert me on articles by topic  Social Bookmarking   What's this?

Mark R. Lesk, MSc, MD; Ali S. Hafez, MD, PhD; Denise Descovich, MD

Arch Ophthalmol. 2006;124:1568-1572.

Objectives  To investigate changes in optic nerve head topography and blood flow after therapeutic intraocular pressure reduction and to correlate them with central corneal thickness.

Methods  Sixteen patients with open-angle glaucoma and 16 patients with ocular hypertension underwent Heidelberg retina tomography and scanning laser Doppler flowmetry in 1 eye before and at least 2 months after a mean 35% sustained therapeutic reduction in intraocular pressure. Patients were assigned to a thin or thick group based on their median central corneal thickness.

Results  Compared with 16 patients with thick corneas (mean ± SD central corneal thickness, 587 ± 31 µm), the 16 patients with thin corneas (518 ± 32 µm) had greater reductions in mean (36 ± 32 vs 4 ± 36 µm, P = .003) and in maximum cup depth (73 ± 107 vs 4 ± 89 µm, P = .02). These changes were not statistically significantly different between the patients with open-angle glaucoma and those with ocular hypertension. Smaller mean ± SD improvements in neuroretinal rim blood flow were seen in patients with thinner corneas compared with those with thicker corneas (35 ± 80 vs 110 ± 111 arbitrary units, P = .04).

Conclusion  Patients with open-angle glaucoma and ocular hypertension with thinner corneas show significantly greater shallowing of the cup, a surrogate marker for lamina cribrosa displacement (compliance), and smaller improvements of neuroretinal rim blood flow after intraocular pressure reduction.

Author Affiliations: Department of Ophthalmology, University of Montreal, and Ophthalmology Research Unit, Centre de Recherche Guy-Bernier, Maisonneuve-Rosemont Hospital, Montreal, Quebec.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Diabetes, Metabolic Abnormalities, and Glaucoma: The Singapore Malay Eye Study
Tan et al.
Arch Ophthalmol 2009;127:1354-1361.
ABSTRACT | FULL TEXT  

Preventing Glaucoma in a High-Risk Population: Impact and Observations of the Ocular Hypertension Treatment Study
Rhee
Arch Ophthalmol 2009;127:216-218.
FULL TEXT  

Corneal Biomechanical Properties and Retinal Vascular Caliber in Children
Lim et al.
IOVS 2009;50:121-125.
ABSTRACT | FULL TEXT  

Estimation of Ocular Rigidity Based on Measurement of Pulse Amplitude Using Pneumotonometry and Fundus Pulse Using Laser Interferometry in Glaucoma
Hommer et al.
IOVS 2008;49:4046-4050.
ABSTRACT | FULL TEXT  

Corneal Hysteresis but Not Corneal Thickness Correlates with Optic Nerve Surface Compliance in Glaucoma Patients
Wells et al.
IOVS 2008;49:3262-3268.
ABSTRACT | FULL TEXT