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Daniel Weisbrod, MD; Charles J. Pavlin, MD; Hugh McGowan, MD; Yeni H. Yücel, MD, PhD, FRCPC

Arch Ophthalmol. 2009;127(8):1064-1066.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Ciliary body and choroidal melanoma account for greater than 90% of all uveal melanomas. Extrascleral extension is an important prognostic factor in uveal melanoma and has been described in 8% of eyes enucleated in the Collaborative Ocular Melanoma Study. Infiltrating solid tumors may cause cellular and degenerative changes in connective tissue surrounding the tumor, contributing to tumor cell invasion.¹ For these reasons, characterization of scleral changes adjacent to the tumor may be relevant to tumor invasion.

Melanoma-associated spongiform scleropathy (MASS) is a histopathological entity described as an area within the sclera adjacent to a choroidal or ciliary body melanoma where collagen fibers appear to have disintegrated into loose fibers.² Melanoma-associated spongiform scleropathy is observed in approximately one-third of eyes with uveal melanoma.^2-3 Biochemical analyses of MASS show decreased collagen and amino acids and increased . . . [Full Text of this Article]

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