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COMMENTS AND OPINIONS
Methodologic Aspects of Glaucoma Phamacogenomic Studies—Reply
Catherine A. McCarty, PhD;
James K. Burmester, PhD;
Bickol N. Mukesh, PhD;
Richard B. Patchett, MD;
Russell A. Wilke, MD, PhD
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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In reply
We welcome the opportunity to address the questions raised by Dr Leffler and to provide further details about our methods, first in relation to the suggestion for additional variables to include in the multivariate analyses. The Personalized Medicine Research Project cohort is 98% white, with 78% reporting German ancestry.1 Only subjects with primary open-angle glaucoma or ocular hypertension were eligible for inclusion in this study, and only 1 eye per subject (the one with the greatest decrease in IOP) was included in the analyses. We acknowledge that baseline IOP was not used directly in multivariate analyses. Our reasoning was that this information was already contained in the relative decrease in IOP and that it was too highly correlated with the relative change to include in the multivariate . . . [Full Text of this Article]
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Intraocular Pressure Response to Topical β-Blockers Associated With an ADRB2 Single-Nucleotide Polymorphism
Catherine A. McCarty, James K. Burmester, Bickol N. Mukesh, Richard B. Patchett, and Russell A. Wilke
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ABSTRACT
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RELATED LETTER
Methodologic Aspects of Glaucoma Phamacogenomic Studies
Christopher T. Leffler
Arch Ophthalmol. 2009;127(5):706.
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