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Christopher T. Leffler, MD, MPH

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

McCarty et al¹ studied the association between intraocular pressure (IOP) response to topical β-blockers and genotype. Several factors are associated with IOP response such as concurrent use of IOP-lowering medication,¹ baseline IOP,^2-4 and cup-disc ratio.⁴ Patients' races were not provided. Whether treatment was monocular might matter because of association with glaucoma type (eg, angle recession) and because binocular treatment provides 2 opportunities for a specified pressure drop. The criteria of McCarty et al might have included patients with ocular hypertension, primary open-angle glaucoma, or glaucoma due to chronic angle closure, pseudoexfoliation, angle recession, pigmentary change, steroid response, uveitis, neovascularization, or other causes. Genotyping will be most helpful when it provides information not already known. Race, concurrent IOP-lowering medication regimen, baseline IOP, type of glaucoma, number of eyes treated, and cup-disc ratio should be controlled for in the multivariable prediction of IOP response (Table 4 of . . . [Full Text of this Article]

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RELATED LETTERS

Intraocular Pressure Response to Topical β-Blockers Associated With an ADRB2 Single-Nucleotide Polymorphism
Catherine A. McCarty, James K. Burmester, Bickol N. Mukesh, Richard B. Patchett, and Russell A. Wilke
Arch Ophthalmol. 2008;126(7):959-963.
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Methodologic Aspects of Glaucoma Phamacogenomic Studies—Reply
Catherine A. McCarty, James K. Burmester, Bickol N. Mukesh, Richard B. Patchett, and Russell A. Wilke
Arch Ophthalmol. 2009;127(5):706-707.
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RELATED ARTICLE

Intraocular Pressure Response to Topical β-Blockers Associated With an ADRB2 Single-Nucleotide Polymorphism
Catherine A. McCarty, James K. Burmester, Bickol N. Mukesh, Richard B. Patchett, and Russell A. Wilke
Arch Ophthalmol. 2008;126(7):959-963.
ABSTRACT | FULL TEXT