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Michael X. Repka, MD; Raymond T. Kraker, MSPH; Roy W. Beck, MD, PhD; Jonathan M. Holmes, BM, BCh; Susan A. Cotter, OD; Eileen E. Birch, PhD; William F. Astle, MD; Danielle L. Chandler, MSPH; Joost Felius, PhD; Robert W. Arnold, MD; D. Robbins Tien, MD; Stephen R. Glaser, MD; for the Pediatric Eye Disease Investigator Group

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In reply

Dr Lempert raises several issues that we believe are either erroneous or not pertinent to the interpretation of our results. He refers to possible selection bias, but does not indicate how that bias, if it existed, might have affected the results. While laboratory research protocols can be designed to remove all potential biases, this is not possible in a human clinical trial. The optimal trial design can minimize but generally not eliminate the potential for bias. Treatment group assignment was determined through randomization of subjects who met prespecified eligibility criteria. It is . . . [Full Text of this Article]

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RELATED LETTER

Potential Bias in Amblyopia Treatment Study
Philip Lempert
Arch Ophthalmol. 2009;127(3):348.
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