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Robert N. Frank, MD

Arch Ophthalmol. 2009;127(3):330-331.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In 1993, the Diabetes Control and Complications Trial's (DCCT’s) demonstration that strict control of blood glucose to near-normal levels during an average of 6.5 years in subjects with type 1 diabetes significantly reduced the progression of retinopathy as well as other chronic microvascular complications of the disease was among the most important results from a randomized controlled clinical trial in medical history.¹ This was followed, a few years later, by the results of another randomized controlled trial, the United Kingdom Prospective Diabetes Study, which demonstrated the same result for subjects with type 2 diabetes.² Together, these 2 trials, now classics of medicine, definitively answered the long-troubling question as to whether maintaining blood glucose level in the near-normal range really does produce beneficial long-term results in diabetic patients.

However, the DCCT researchers and their devoted volunteer subjects were not satisfied with that single dramatic result. Well after . . . [Full Text of this Article]

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