• Online Features  This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Neurology  • Retinal/ Chorioretinal Disorders  • Surgery  • Neurosurgery  • Drug Therapy  • Adverse Effects  • Alert me on articles by topic  Social Bookmarking   What's this?

Shantan Reddy, MD, MPH; Darin R. Goldman, MD; Andrew Kaines, MD; Jean-Pierre Hubschman, MD; David Sarraf, MD

Arch Ophthalmol. 2009;127(11):1550-1551.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Papaverine hydrochloride, a potent vasodilator whose mechanism of action is thought to arise from inhibition of cyclic adenosine monophosphate and cyclic guanosine monophosphate phosphodiesterases in smooth muscle, is the most researched pharmacologic agent for the treatment of cerebral vasospasm. The successful use of intracranial irrigation of papaverine by neurosurgeons to prevent vasospasm after clipping of a cerebral aneurysm has been demonstrated, leading to its widespread use.¹ Although it is gaining popularity, its ocular complications still remain unclear. Transient cranial nerve palsies have been documented after papaverine irrigation. These cranial nerve abnormalities include facial nerve palsy and ipsilateral, bilateral, and contralateral pupillary dilation.^2-3 One case of unexplained transient monocular blindness has been reported.¹ We report a new concern of choroidal infarction causing permanent vision loss after intracranial irrigation with papaverine.

Report of a Case

A 55-year-old woman with . . . [Full Text of this Article]

Comment

AUTHOR INFORMATION


CiteULike    Connotea    Delicious    Digg    Facebook    Reddit    Technorati    Twitter     What's this?