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Tony Tsai, MD; Joan M. O’Brien, MD

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In reply

We thank Damato and Coupland for their thoughtful comments on the issue of genetic prognostication for patients with uveal melanoma.

The benefits of any diagnostic test must be viewed in the context of the risks of its performance. We agree that genetic analysis is a powerful tool for providing prognostic information for patients with uveal melanoma. There is no reason to avoid tumor genotyping for the patient who understands the implications and limitations of the prognostic information and when no additional risk is required to obtain tissue for analysis, as is the case when enucleation or resection is the selected tumor treatment. However, much of the current controversy surrounds the use of fine-needle aspiration biopsy (FNAB) to add prognostic information when the diagnosis of uveal melanoma has been established noninvasively. Although FNAB has a long history of use for intraocular tumors . . . [Full Text of this Article]

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