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Jerry A. Shields, MD; Carol L. Shields, MD; Miguel Materin, MD; Takami Sato, MD; Arupa Ganguly, PhD

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In reply

We appreciate the comments of Damato and Coupland regarding the controversial issues related to cytogenetics of uveal melanoma. It appears that they basically agree with our views on this subject, but have concerns regarding the comments of Robertson and Tsai and of O’Brien.^1-3

A couple of points require further comment.

We continue to advocate medical follow-up for patients with uveal melanoma with both disomy 3 and monosomy 3 abnormality. Our evaluations of those patients currently include physical examination and laboratory testing for lactate dehydrogenase and alkaline phosphatase levels twice per year, and a chest x-ray and abdominal imaging with ultrasound, computed tomography, or magnetic resonance imaging once per year. This evaluation is offered because some patients with disomy 3 melanoma will develop metastasis. Furthermore, most patients with cancer desire systemic monitoring . . . [Full Text of this Article]

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