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Corneal Cupremia in Multiple Myeloma: A Clinicopathologic Correlation
Rona Z. Silkiss, MD;
Dustin Pomerleau, MD;
Andrew Sorenson, MD;
David Vastine, MD;
J. Brooks Crawford, MD
Arch Ophthalmol. 2008;126(7):1005-1006.
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We describe the study of an eye from a patient with corneal cupremia secondary to multiple myeloma. An intercurrent episode of mucormycosis necessitated removal of this individual's eye, enabling this unique study.
Report of a Case
A 71-year-old white woman with an 8-year history of refractory multiple myeloma had blurred vision. Her best-corrected visual acuity was 20/30 OU. In both eyes, the cornea manifested a remarkable golden-brown, metallic sheen that on slitlamp examination was determined to be at the level of the Descemet membrane (Figure 1). The remainder of her examination disclosed no abnormalities. Several months later, the patient's vision rapidly decreased and she was diagnosed with mucormycosis of the orbit and sinus. Despite aggressive sinus and orbit débridement as well as the use of antifungal agents, the patient required exenteration. The exenteration specimen provided . . . [Full Text of this Article] Comment
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