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Applications for Studying Retinal Degeneration

Arch Ophthalmol. 2008;126(6):857-858.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Invest Ophthalmol Vis Sci

High-Resolution Imaging With Adaptive Optics in Patients With Inherited Retinal Degeneration

Jacque L. Duncan; Yuhua Zhang; Jarel Gandhi; Chiaki Nakanishi; Mohammad Othman; Kari E. H. Branham; Anand Swaroop; Austin Roorda

Purpose: To investigate macular photoreceptor structure in patients with inherited retinal degeneration using high-resolution images and to correlate the findings with clinical phenotypes and genetic mutations.

Methods: Adaptive optics scanning laser ophthalmoscopy (AOSLO) images of photoreceptors were obtained in 16 eyes: 5 with retinitis pigmentosa (RP), 3 with cone-rod dystrophy (CRD), and 8 without retinal disease. A quadratic model was used to illustrate cone spacing as a function of retinal eccentricity. Cone spacing at 1° eccentricity was compared with standard measures of central visual function, including best-corrected visual acuity (BCVA), foveal threshold, and multifocal electroretinogram (mfERG) amplitude and timing. Intervisit variations were studied in 1 patient with RP and 1 patient with CRD. Screening of candidate . . . [Full Text of this Article]

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