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Michael A. Kass, MD; Mae O. Gordon, PhD; for the Ocular Hypertension Treatment Study Group

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Dr Sommer¹ reminds us that associations found in large data sets may not be correct or causally related. He also points out the need for common sense when interpreting data from clinical trials or epidemiologic studies. He believes that investigators of the Ocular Hypertension Treatment Study (OHTS) may not have followed these admonitions.

One of the major goals of the OHTS was to understand the factors associated with the development of primary open-angle glaucoma (POAG) in individuals with ocular hypertension.² There is an extensive literature on diabetes mellitus and the risk of POAG. Unfortunately, the literature is contradictory, and it is difficult to draw conclusions about this association. Therefore, we thought it was important to assess this association in the OHTS. In our initial analysis published in 2002,³ we used patient self-report of diabetes. Dr . . . [Full Text of this Article]

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