This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Endophthalmitis  • Drug Therapy  • Drug Therapy, Other  • Alert me on articles by topic  Social Bookmarking   What's this?

Rohan W. Essex, MBBS, FRANZCO; Ecosse Lamoureux, PhD; Patrick G. P. Charles, MBBS, FRACP; Penny Allen, MBBS, FRANZCO

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

I would like to commend Soheilian et al¹ for their efforts in attempting to answer an important question in the management of open-globe injuries. However, the methods used in the study are inconclusive, the antibiotic choice was unconventional, and the data appear to contain errors.

The choice of control therapy—intraocular injection of balanced salt solution (BSS)—does not reflect the usual standard of care. A more appropriate control would have been no injection. A valid alternative conclusion from this study would be that intraocular BSS injection increases the incidence of endophthalmitis. At the very least, thistherapy exposed the control group unnecessarily to the risks of intraocular injection.

Gentamicin sulfate has a well-documented incidence of macular toxicity. A low dose was therefore used.² Safer antibiotics are available. A combination such as vancomycin hydrochloride at . . . [Full Text of this Article]

AUTHOR INFORMATION


CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?