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Paulus T. V. M. de Jong, MD, PhD; Caroline A. A. Hulsman, MD, PhD; Albert Hofman, MD, PhD; Jacqueline C. M. Witteman, PhD; Johannes R. Vingerling, MD, PhD

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We thank Drs Sommer and Tielsch for their suggestion to use high perfusion pressure as a continuous variable while analyzing its relationship to POAG and for reminding us of their hypothesis that the association between systemic hypertension and POAG might depend on age.¹ They showed that the odds ratio for POAG went up to 6.2 (with wide 95% confidence intervals) when the diastolic perfusion pressure (diastolic blood pressure – intraocular pressure) dropped below 50 mm Hg.¹ They also demonstrated a nonsignificant inverse association between systemic hypertension and POAG in persons younger than 60 years and a positive association in persons older than 70 years.¹ Their younger-age hypothesis with regards to systemic hypertension and POAG could not be confirmed in the cross-sectional Barbados . . . [Full Text of this Article]

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