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What Future Discoveries Lie on the Horizon?

Shigeru Kinoshita, MD, PhD

Arch Ophthalmol. 2008;126(5):725-726.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Since 1986, when the "presumed corneal epithelial stem cell (CESC) location in mice" was first described by Sun and colleagues,¹ we ophthalmologists have witnessed a long and exciting history of investigation into the exact location of CESC. The results of this extensive amount of cutting-edge research have led to phenomenal correspondent advancements in the basic understanding of devastating ocular surface disorders and clinical applications for tissue engineering and regenerative medicine. Thanks to the fascinating findings reported by epithelial biologists worldwide who used convincing experimental techniques, such as unique keratin expression and slow-cycling cell labeling using mouse models,² it has now been elucidated that CESC are located in the limbal region. Initially, most researchers thought that limbal epithelial basal cells (LEBC) were, in fact, CESC; however, it was discovered that only 1% to 2% of LEBC are CESC. Interestingly, it has been shown through a refined side-population . . . [Full Text of this Article]

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