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Johannes R. Vingerling, MD; Sarah Owens, MD; Willem I. van der Meijden, MD; Carel B. Hoyng, MD; Alan C. Bird, MD

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In a nicely illustrated Photo Essay, Ciardella et al¹ described a Hispanic woman with extensive cutaneous vitiligo and choroidal hypopigmentation bilaterally. The authors suggest that the changes in the choroid and skin may have a common etiological root in the neural crest cells. The role of the retinal pigment epithelium (RPE) cells in these patients remains unclear. Recently we described 2 very similar cases with cutaneous vitiligo and choroidal hypopigmentation.² They both had normal visual function and additional fluorescein angiogram and electrodiagnostic test results were normal. Based on these findings, we concluded that the RPE was not involved and that the lack of pigment was confined to the choroid in these cases. We suggested that this may occur because both choroidal and skin melanocytes are derived from neural crest . . . [Full Text of this Article]

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