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Jerry A. Shields, MD; Carol L. Shields, MD; Miguel Materin, MD; Takami Sato, MD; Arupa Ganguly, PhD

Arch Ophthalmol. 2008;126(3):416-419.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Uveal melanoma is one of the few conditions diagnosed by eye care specialists that carries a guarded prognosis for life. Although most patients are apparently healthy at the time of diagnosis, 10-year tumor-related death from posterior uveal melanoma ranges from 20% to greater than 50%.^1-3

The management of posterior uveal melanoma has been controversial. Several years ago, heated debates erupted between 2 diametrically opposed schools of thought. One group favored prompt enucleation of virtually all melanocytic uveal lesions that were suspected to be melanomas.^4-5 The other group preferred observation of many small- and medium-sized tumors to document growth before initiating treatment^6-8; they proposed that enucleation might not improve the prognosis and could even accelerate dissemination of the neoplasm.⁶ The philosophy of "observation until growth is documented" has prevailed in ophthalmology during the . . . [Full Text of this Article]

RECENT DEVELOPMENTS IN CYTOGENETICS


CURRENT CLINICAL APPLICATIONS

AUTHOR INFORMATION
Author Affiliations: The Ocular Oncology Service, Wills Eye Institute (Drs J. A. Shields, C. L. Shields, and Materin), and the Department of Medical Oncology (Dr Sato), Thomas Jefferson University; and the Department of Genetics, University of Pennsylvania (Dr Ganguly), Philadelphia, Pennsylvania.

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