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Mae O. Gordon, PhD; Julia A. Beiser; Michael A. Kass, MD; for the Ocular Hypertension Treatment Study Group

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In 2002, the Ocular Hypertension Treatment Study¹ (OHTS) reported baseline factors that increased the risk for developing primary open-angle glaucoma (POAG): older age, a larger vertical cup-disc ratio, higher intraocular pressure, greater Humphrey visual field pattern standard deviation, and a thinner central corneal measurement. A history of diabetes mellitus at baseline appeared to be protective against developing POAG. Six of the 191 participants (3.1%) who reported diabetes mellitus at baseline developed POAG compared with 119 of the 1427 participants (8.3%) who did not (multivariate hazard ratio, 0.37; 95% confidence interval, 0.15-0.90). This finding was unexpected and contradicted most of the literature on risk factors for POAG.^2-4

The 2002 article acknowledged methodological issues in the OHTS that might account for this finding. Participants were classified at baseline as having a positive history of . . . [Full Text of this Article]

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