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MisclassificationWho Really Lives in This Neighborhood?
Alfred Sommer, MD, MHS
Arch Ophthalmol. 2008;126(2):265-266.
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My ophthalmologic career might well have ended before it truly began. In an editorial prepared as a second-year resident, I decried the sorry state of clinical research (citing the shortcomings of published articles by leading academics) and called for the rigorous application of epidemiologic and statistical principles.1 Fortunately, those cited withheld retribution and, more often than not, graciously encouraged my efforts.
That led to my preparing a primer on basic epidemiologic and statistical principles for use by ophthalmic investigators (and their readers).2 The most basic principle of all was that epidemiology was "a peculiarly thoughtful approach to studies amounting to applied common sense."2(p3)
Quantitative rigor and "common sense" now permeate ophthalmic research and are responsible for a significant share of our understanding of the magnitude, distribution, causes, and appropriate treatment of disease. But to an alarming degree, growth in the quantity of "epidemiologic" data has diminished . . . [Full Text of this Article]
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