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Stefano Miglior, MD

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The recent article by Hong et al¹ describes the relevance of long-term fluctuations in intraocular pressure (IOP) on glaucoma progression, but their findings need further clarification.

The study provides no information about the clinical history of the 408 patients during the 9 years of follow-up but it would be surprising if none of them showed any progressive visual field (VF) change using standard clinical criteria. If such a change did occur, more intense IOP-lowering therapy would probably have been started, thus inducing a greater fluctuation. Unfortunately, nothing is said as to whether the analysis included IOP measurements made after the VF progression observed at the time of clinical follow-up. This was done in AGIS,² which found that long-term IOP fluctuations were a risk factor for progression, but not in the EMGT³ or EGPS⁴ (which did not confirm the risk), and retrospective reevaluation by means of a new . . . [Full Text of this Article]

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