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COMMENTS AND OPINIONS
Inconsistencies and Gaps in Evidence Concerning Vitamins and Risk of Cataract—Reply
William Christen, PhD
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In reply
Drs Masket and Lum correctly note that observational studies are susceptible to the distorting effects of known and unknown confounders. For this reason, randomized trials are required to detect reliably the most likely small to moderate benefits that may accrue for higher dietary or supplemental intake of various nutrients including lutein/zeaxanthin and vitamin E. As further noted by Drs Masket and Lum, randomized trial data have been disappointing for vitamin E and are not yet available for lutein/zeaxanthin.
With respect to our methodology for identifying cataract,1 it is not feasible to conduct eye examinations on all study participants in our large cohorts of men and women. Instead, medical record data are collected to confirm participant reports of cataract. The fact that this methodology has identified important risk factors for cataract such as cigarette smoking and body weight, associations also demonstrated in examined populations, provides reassuring . . . [Full Text of this Article]
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ABSTRACT
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RELATED LETTER
Inconsistencies and Gaps in Evidence Concerning Vitamins and Risk of Cataract
Samuel Masket and Flora Lum
Arch Ophthalmol. 2008;126(11):1606-1607.
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